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December 14, 2009Journal of General Internal Medicine407 citationsOpen Access

Hospital Readmission in General Medicine Patients: A Prediction Model

OHOmar HasanDMDavid O. MeltzerSSShimon Shaykevich

Key Result

A 7-factor prediction model identified 5.1% of general medicine patients with a score ≥25 who had a ~30% risk of 30-day hospital readmission, with fair discrimination (c-statistic 0.61-0.65).

Key Points

  • The aim is to identify early hospital readmission predictors in a broad patient population and create a simple risk assessment model.
  • Prospective observational cohort study with 10,946 patients discharged from general medicine services.
  • Patients were randomly divided into derivation (n=7,287) and validation (n=3,659) cohorts.
  • Logistic regression analysis identified predictors of 30-day unplanned readmission.
  • 17.5% of patients experienced readmission in each cohort.
  • Cumulative risk score >or=25 points identified 5% of patients with a readmission risk of ~30%.
  • Model discrimination was fair with c-statistics of 0.65 for the derivation cohort and 0.61 for the validation cohort.

Study Design

Type

Cohort (n=10,946)

Multicenter

Yes

Structured PICO

P
Population
10,946 adult patients (≥18 years of age) discharged home from general medicine services at six academic medical centers, randomly divided into derivation (n=7,287) and validation (n=3,659) cohorts.
O
Outcome
All-cause admission to an acute care hospital within 30 days of discharge from the index hospitalization

A simple 7-factor prediction model using easily available admission data can identify general medicine patients at high risk for 30-day hospital readmission, though overall model discrimination is fair.

Limitations

  • Limited generalizability to small, rural, or community hospitals
  • Sizeable proportion of screened patients could not be included
  • Excluded patients who died within 30 days of discharge
  • Did not adjudicate elective versus unplanned readmissions
  • Unable to confirm readmissions to non-study hospitals
  • Model discrimination was only fair (AUC 0.61-0.65)

Abstract

BACKGROUND: Previous studies of hospital readmission have focused on specific conditions or populations and generated complex prediction models. OBJECTIVE: To identify predictors of early hospital readmission in a diverse patient population and derive and validate a simple model for identifying patients at high readmission risk. DESIGN: Prospective observational cohort study. PATIENTS: Participants encompassed 10,946 patients discharged home from general medicine services at six academic medical centers and were randomly divided into derivation (n = 7,287) and validation (n = 3,659) cohorts. MEASUREMENTS: We identified readmissions from administrative data and 30-day post-discharge telephone follow-up. Patient-level factors were grouped into four categories: sociodemographic factors, social support, health condition, and healthcare utilization. We performed logistic regression analysis to identify significant predictors of unplanned readmission within 30 days of discharge and developed a scoring system for estimating readmission risk. RESULTS: Approximately 17.5% of patients were readmitted in each cohort. Among patients in the derivation cohort, seven factors emerged as significant predictors of early readmission: insurance status, marital status, having a regular physician, Charlson comorbidity index, SF12 physical component score, >or=1 admission(s) within the last year, and current length of stay >2 days. A cumulative risk score of >or=25 points identified 5% of patients with a readmission risk of approximately 30% in each cohort. Model discrimination was fair with a c-statistic of 0.65 and 0.61 for the derivation and validation cohorts, respectively. CONCLUSIONS: Select patient characteristics easily available shortly after admission can be used to identify a subset of patients at elevated risk of early readmission. This information may guide the efficient use of interventions to prevent readmission.

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Cite This Study

Hasan et al. (2009) conducted a cohort in General medicine patients at risk of hospital readmission (n=10,946). 7-factor readmission risk prediction model was evaluated on 30-day hospital readmission. A 7-factor prediction model identified 5.1% of general medicine patients with a score ≥25 who had a ~30% risk of 30-day hospital readmission, with fair discrimination (c-statistic 0.61-0.65).

synapsesocial.com/papers/6a09bd5e36c3abab5045fda4https://doi.org/10.1007/s11606-009-1196-1
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