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October 29, 2025PLoS ONE4 citationsOpen Access

Hypertension screening across different age groups in Indian adults: Evidence from nationally representative cross-sectional data

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PMPrakash MathiyalagenARAnand RajagopalKVKavita Vasudevan

Key Result

Routine hypertension screening in Indian adults is optimally initiated at 35 years of age, based on ROC analysis demonstrating balanced sensitivity and specificity for early detection.

Study Design

Type

Cross-Sectional (n=825,954)

Multicenter

Yes

Structured PICO

P
Population
825,954 Indian adults (1,01,839 men and 7,24,115 women) aged 15 years and above from the fifth National Family Health Survey (NFHS-5)
O
Outcome
Optimal age for initiating hypertension screening (determined by ROC analysis) and factors associated with hypertension

Based on nationally representative data, routine hypertension screening in Indian adults should be initiated at 35 years of age to optimize early detection.

Abstract

BACKGROUND: Hypertension is a significant public health concern globally and in India, contributing substantially to the burden of cardiovascular diseases. Early detection through appropriate screening practices is critical to mitigating its long-term impact. However, there is limited evidence on age-specific screening practices for hypertension in the Indian population. This study aims to assess hypertension screening practices across different age groups and identify associated socio-demographic, behavioral, and physiological factors to inform effective public health strategies. METHODS: A cross-sectional study was conducted using data from the fifth National Family Health Survey (NFHS-5), which included 1,01,839 men and 7,24,115 women aged 15 years and above. Hypertension was defined based on systolic blood pressure (SBP) ≥140 mmHg and/or diastolic blood pressure (DBP) ≥90 mmHg. Multivariate logistic regression was used to analyze associations between hypertension and various socio-demographic and behavioral factors. Receiver Operating Characteristic (ROC) analysis determined the optimal age for initiating hypertension screening. RESULTS: The prevalence of hypertension increased linearly with age, with a significant rise observed in the 35-39 years age group. Factors significantly associated with hypertension included marital status, religion, education, wealth index, alcohol consumption, and waist-hip ratio. ROC analysis identified 35 years as the optimal age for initiating routine hypertension screening in both men and women. Screening in this age group showed balanced sensitivity and specificity for early detection of hypertension. CONCLUSIONS: This study highlights the need to revise hypertension screening policies in India, recommending initiation at 35 years to improve early detection and management. Addressing socio-demographic and lifestyle determinants through targeted interventions is critical to achieving national hypertension control goals.

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Cite This Study

Mathiyalagen et al. (2025) conducted a cross-sectional in Hypertension (n=825,954). Hypertension screening was evaluated on Optimal age for initiating hypertension screening. Routine hypertension screening in Indian adults is optimally initiated at 35 years of age, based on ROC analysis demonstrating balanced sensitivity and specificity for early detection.

synapsesocial.com/papers/6a09dc2059b902245b4630bfhttps://doi.org/10.1371/journal.pone.0332226
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