Cardiac troponin I concentrations were elevated above reference intervals in 70% of dogs and cats with azotaemic renal failure and 70% of dogs with systemic non-cardiac diseases.
Cross-Sectional (n=70)
Are cardiac troponin I levels elevated in dogs and cats with azotaemic renal failure or other severe non-cardiac disease without clinical evidence of cardiac disease?
Cardiac troponin I is frequently elevated in dogs and cats with severe non-cardiac illnesses such as azotaemic renal failure, suggesting subclinical myocardial injury or altered clearance.
OBJECTIVE: To determine if dogs and cats with renal failure, or other severe non-cardiac disease, and no antemortem evidence of cardiac disease on basic clinical evaluation, have elevated levels of cardiac troponin I (cTnI). DESIGN: Cross-sectional study using 56 dogs and 14 cats with primary non-cardiac disease (39 dogs with azotaemic renal failure, 14 cats with azotaemic renal failure, 17 dogs with non-cardiac systemic disease); 7/25 dogs and 6/14 cats had murmurs detected on physical examination. Serum or heparinised plasma was collected and analysed for cTnI. RESULTS: Cardiac troponin I concentrations were elevated above reference intervals in 70% of dogs and 70% of cats with azotaemic renal failure and in 70% of dogs with a variety of systemic non-cardiac diseases. Cardiac troponin I concentrations did not correlate with the degree of azotaemia, presence of murmurs, hypertension or type of non-cardiac illness. CONCLUSIONS: Cardiac troponin I concentration is often elevated in dogs and cats with azotaemic renal failure and in dogs with other systemic non-cardiac illness, suggesting that these conditions often result in clinically inapparent myocardial injury or possibly altered elimination of cTnI.
Porciello et al. (2008) conducted a cross-sectional in Azotaemic renal failure and non-cardiac systemic disease (n=70). Cardiac troponin I (cTnI) measurement was evaluated on Cardiac troponin I concentrations elevated above reference intervals. Cardiac troponin I concentrations were elevated above reference intervals in 70% of dogs and cats with azotaemic renal failure and 70% of dogs with systemic non-cardiac diseases.