IV thrombolysis for acute ischemic stroke after dabigatran reversal with idarucizumab appears safe and effective, though robust evidence from randomized-controlled trials is currently lacking.
Meta-Analysis
Does IV thrombolysis after dabigatran reversal with idarucizumab improve functional outcomes and maintain safety in patients with acute ischemic stroke compared to IVT without dabigatran pretreatment?
IV thrombolysis for acute ischemic stroke after dabigatran reversal with idarucizumab appears safe and effective based on observational data.
BACKGROUND AND OBJECTIVES: Limited data exist on the safety of IV thrombolysis (IVT) for acute ischemic stroke (AIS) after dabigatran reversal with idarucizumab. We sought to evaluate the safety and efficacy of idarucizumab pretreatment in patients with AIS receiving IVT. METHODS: A national registry-based study evaluated the safety and efficacy of IVT in this specific subgroup. We also conducted a systematic review and meta-analysis of cohort studies and case series, aiming to document the pooled rates of (1) symptomatic intracranial hemorrhage (sICH), (2) any intracranial hemorrhage, (3) 3-month mortality, and (4) the proportion of excellent (modified Rankin Scale mRS scores 0-1) and (5) good (mRS scores 0-2) functional outcome at 3 months among patients with AIS, who received IVT after dabigatran reversal with idarucizumab. Moreover, we sought to compare these outcomes between IVT-treated patients after dabigatran reversal with idarucizumab and IVT-treated patients without dabigatran pretreatment. RESULTS: = 27%). DISCUSSION: IVT for AIS after dabigatran reversal with idarucizumab seems to be safe and effective in observational studies with limited number of patients. Randomized-controlled clinical trials are warranted to provide robust evidence on the safety and efficacy of IVT in this specific AIS subgroup.
Theodorou et al. (2024) conducted a meta-analysis in Acute ischemic stroke. IV thrombolysis after dabigatran reversal with idarucizumab vs. IV thrombolysis without dabigatran pretreatment was evaluated on Symptomatic intracranial hemorrhage, any intracranial hemorrhage, 3-month mortality, and functional outcome. IV thrombolysis for acute ischemic stroke after dabigatran reversal with idarucizumab appears safe and effective, though robust evidence from randomized-controlled trials is currently lacking.