G type-specific antibody responses to the outbreak strain occurred in 79% of rotavirus-infected children compared to 9% of children with undetected infection (P < .001).
Cohort (n=63)
Yes
Do specific anti-rotavirus antibody levels correlate with protection against natural rotavirus infection and illness in children?
Higher levels of specific anti-rotavirus antibodies, including IgA, IgG, and homotypic antibodies, correlate with protection against natural rotavirus infection and illness in children.
Absolute Event Rate: 79% vs 9%
p-value: p=< .001
Serum VP7 (G) type- and isotype-specific anti-rotavirus antibodies were assessed among children monitored longitudinally over one or two rotavirus seasons in day care centers. Seventy-five pairs of blood specimens from 63 children were tested for anti-rotavirus antibodies. Stool specimens were collected weekly and tested for rotavirus antigen. G typing of detected rotaviruses showed that seven outbreaks of G1 and one of G3 occurred during the two seasons. G type-specific responses to the outbreak strain occurred among 79% of infected children and 9% of children with infection not detected (P < .001). Of children infected with G1, 54% had a heterotypic response; they were older (P = .048) and had higher preexisting G1 antibody levels than children who had only homotypic responses (P = .012). Higher IgA, IgG, and homotypic antibody levels to the antigenic site C of the G1 and G3 VP7s correlated with protection against infection and illness, homotypic antibody independently of IgA or IgG titers.
O’Ryan et al. (1994) conducted a cohort in Natural Rotavirus Infections (n=63). Natural rotavirus infection vs. No detected infection was evaluated on G type-specific responses to the outbreak strain (p=< .001). G type-specific antibody responses to the outbreak strain occurred in 79% of rotavirus-infected children compared to 9% of children with undetected infection (P < .001).