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May 18, 2026Stem Cell Reports0 citationsOpen Access

PrPC-facilitated cell signaling activates phospholipase Cɣ1 and triggers an Arc/Arg3.1 response in mouse and iPSC-derived human neurons

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DODaniel Ojeda-JuárezGFGail FunkDMDaniel B. McClatchy

Key Points

  • This research aims to investigate how PrPC influences cell signaling and its effects on neuronal activity.
  • Utilized mouse and iPSC-derived human neurons for analysis.
  • Examined the role of phospholipase Cɣ1 in signaling pathways triggered by PrPC.
  • Evaluated the Arc/Arg3.1 response linked to neuronal hyperactivity.
  • Activation of phospholipase Cɣ1 is associated with increased neuronal signaling activity.
  • Indicated rapid signaling events leading to enhancements in Arc/Arg3.1 expression.
  • Showed PLC-γ1 as a promising therapeutic target for disorders related to neuronal hyperactivity.

Abstract

, trigger rapid signaling events linked to neuronal hyperactivity in human neurons, and indicate PLC-γ1 as a potential therapeutic target.

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Cite This Study

Ojeda-Juárez et al. (2026) studied this question.

synapsesocial.com/papers/6a0aac2b5ba8ef6d83b6fb76https://doi.org/10.1016/j.stemcr.2026.102924
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