The provided text contains only journal masthead and editorial board information, with no clinical study data.
Patients with acute myocardial infarction demonstrate a greater tendency for in vitro platelet release in the acute phase, which normalizes by 6 months.
Summary In vivo platelet activity was studied in 58 patients with AMI on admittance to the Coronary Care Unit, in 48 of these patients after 1 week, in 30 after 1 month and in 24 patients after 6 months. Patients were carefully selected and excluded if they had associated diseases known to increase platelet activity. In vivo activation was studied by evaluating the plasma concentration of beta-thromboglobulin (β-TG) and platelet factor 4 (PF4) in the same blood sample. On admittance (x = 58.5) and on day 7 (x = 52.9) β-TG values were significantly higher than those obtained in the control group (x = 29). β-TG values were moderately elevated after 1 month (x = 37.7) and then returned to values similar to those of the control group after 6 months (x = 27.9). The simultaneous assessment of PF4 shows a β-TG/PF4 ratio indicative for in vitro release (≤2.5) in many patients on days 1 and 7. Moreover, the β-TG/PF4 ratio in patients with AMI tends towards 2 when β-TG values are high. These results may indicate a greater tendency to an in vitro platelet release in the acute phase of AMI.
Pengo et al. (1985) studied this question. The provided text contains only journal masthead and editorial board information, with no clinical study data.