Why the study?
Does chronic nitroglycerin treatment affect the sGC-cGK-I signaling pathway and superoxide formation in rat and rabbit aortas?
Population
Rats and rabbits
Comparison
3-day nitroglycerin treatment, with or without… vs Control (implied)
Design
Preclinical
Follow-up
3 days
Key result
Chronic 3-day nitroglycerin treatment in rats and rabbits increased sGC expression and reduced VASP phosphorylation, reflecting chronic inhibition of the sGC-cGK-I pathway.
Authors
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May contribute to nitrate tolerance; leaves open human relevance and antioxidant mitigation.
Does chronic nitroglycerin treatment affect the sGC-cGK-I signaling pathway and superoxide formation in rat and rabbit aortas?
Chronic nitroglycerin treatment induces tolerance via increased vascular superoxide and chronic inhibition of the sGC-cGK-I pathway, which can be partially mitigated by vitamin C.
Mülsch et al. (2001) studied Nitrate tolerance. Nitroglycerin (NTG) was evaluated on Activity and expression of soluble guanylyl cyclase (sGC), cGMP-activated protein kinase I (cGK-I), and vasodilator-stimulated phosphoprotein (VASP) phosphorylation. Chronic 3-day nitroglycerin treatment in rats and rabbits increased sGC expression and reduced VASP phosphorylation, reflecting chronic inhibition of the sGC-cGK-I pathway.