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February 1, 1998Annual Review of Psychology1,587 citations

Comorbidity of Anxiety and Unipolar Mood Disorders

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SMSusan MinekaDWDavid WatsonLCLee Anna Clark

Key Points

  • This research aims to explore the relationships between anxiety and depression, focusing on their comorbidity and underlying genetic factors.
  • Analyzed existing literature on anxiety and depression since the 1980s.
  • Identified common genetic diatheses and phenotypic models of these disorders.
  • Reviewed studies on cognitive processing related to mood and anxiety.
  • Generalized anxiety and major depression share a common genetic diathesis.
  • Anxiety disorders exhibit genetic heterogeneity, making their classification complex.
  • Cognitive models show that anxiety and depression influence information processing differently.

Abstract

Research on relationships between anxiety and depression has proceeded at a rapid pace since the 1980s. The similarities and differences between these two conditions, as well as many of the important features of the comorbidity of these disorders, are well understood. The genotypic structure of anxiety and depression is also fairly well documented. Generalized anxiety and major depression share a common genetic diathesis, but the anxiety disorders themselves are genetically hetergeneous. Sophisticated phenotypic models have also emerged, with data converging on an integrative hierarchical model of mood and anxiety disorders in which each individual syndrome contains both a common and a unique component. Finally, considerable progress has been made in understanding cognitive aspects of these disorders. This work has focused on both the cognitive content of anxiety and depression and on the effects that anxiety and depression have on information processing for mood-congruent material.

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Cite This Study

Mineka et al. (1998) studied this question.

synapsesocial.com/papers/6a0c1baff84e7d4200884ca7https://doi.org/10.1146/annurev.psych.49.1.377
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