Monocytes contribute to thrombotic disorders by providing tissue factor, forming prothrombotic monocyte-platelet aggregates, linking inflammation to procoagulant states, and aiding recanalisation.
Although, the main physiological role of monocytes is attributed to innate immunity (that is, phagocytosis) and the development of tissue macrophages and dendritic cells, the pathophysiological role of these goes far behind these (simplistic) limits. Indeed, monocytes constitute a major source of blood tissue factor, a key element of the extrinsic coagulation cascade. Monocytes actively bind to platelets, thus forming very prothrombotic monocyte-platelet aggregates. Additionally, these cells link inflammation and the procoagulant state observed in various prothrombotic conditions. However, monocytes are also crucial for successful thrombus recanalisation. In this article, we review the available data on potential mechanisms that link monocytes with thrombosis-related processes.
Lip et al. (2009) conducted a review in Thrombotic disorders. Monocytes was evaluated. Monocytes contribute to thrombotic disorders by providing tissue factor, forming prothrombotic monocyte-platelet aggregates, linking inflammation to procoagulant states, and aiding recanalisation.