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May 20, 2026Autophagy1 citations

PTK2/FAK inhibition triggers TMED9-mediated protective autophagy in pancreatic cancer cell via enhancing ERGIC-ERES contact

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MWMing-Yue WuArmy Medical UniversityWTWan TangArmy Medical UniversityXZXiaowen ZhangMinistry of Education of the People's Republic of China

Key Points

  • This research investigates the mechanism behind FAK inhibition-induced autophagy in pancreatic cancer cells, focusing on TMED9's role.
  • Inhibition of PTK2/FAK was conducted in pancreatic cancer cell lines.
  • Changes in autophagy markers and ERGIC-ERES contact were analyzed post-treatment.
  • FAK inhibition enhanced TMED9 expression, increasing protective autophagy in treated cells.
  • Autophagy markers were significantly elevated, indicating successful induction of the process.

Abstract

. Collectively, our work unveils a previously unrecognized mechanism of FAKi-mediated autophagy induction and provides new insights for developing targeted therapies against PDAC.

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Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/6a0d50f3f03e14405aa9d222https://doi.org/10.1080/15548627.2026.2676079
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