C61-09 Incidence of Cystic Fibrosis Over the Last 5 Years in Colombia

Abstract Introduction Cystic fibrosis (CF) is an autosomal recessive disease characterized by multi-organ involvement and, depending on the clinical spectrum of the disease, can lead to high morbidity and mortality. In Colombia, up to date, no neonatal screening program has been implemented and diagnosis depends on symptoms, delaying the start of treatment. The objective of our study is to evaluate the incidence of the disease over the last 5 years in Colombia. Methodology Records from Sivigila, the Colombian government’s official source of information, were evaluated. All children diagnosed with CF were included and incidence was calculated based on data on live births per year provided by the Departamento Administrativo Nacional de Estadística (DANE), the official Colombian Statistics Agency. Results Between 2020 and 2025, 194 patients diagnosed with cystic fibrosis were reported to Sivigila in Colombia. The distribution of reports by year and the incidence of the disease are shown in Figure 1. 105 patients (54.1%) were male. 99.5% of the children were Colombian. The regions with the highest number of children were Antioquia, with 44 patients (22.7%), and Bogotá DC, with 42 (21.6%); However, Bogotá reported 72 patients (37.1%), and Antioquia 46 (32.7%). The median age at the time of notification was 2 years, with a minimum of 1 month and a maximum of 17 years. Figure # Distribution and incidence of cystic fibrosis. Discussion There was an increase in the incidence of CF (4.13 to 9.91), showing an improvement in the clinical-paraclinical-genetic diagnosis of the disease. The median report at 2 years of age shows an important delay in the diagnosis, being necessary the implementation of a neonatal screening. A centralization in the diagnosis and reporting of CF is described, demonstrating an inequality in the access to this type of diagnosis in the country, contributing to the underreporting of the disease. This is an important structural limitation, demonstrating the need to raise awareness of the disease, access to technology, and the need for neonatal screening. This abstract is funded by: None