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May 20, 2026Foodborne Pathogens and Disease0 citations

Comparative Human-Poultry Fecal Resistome Profiling from Broiler Farms Reveals Diverse Antimicrobial Resistance Genes

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SSSreejith SreekumaranMahatma Gandhi UniversityPVPriya V.K.Mahatma Gandhi UniversityAMAnisha M.N.Mahatma Gandhi University

Key Points

  • This study aims to analyze the diversity of antimicrobial resistance genes in fecal samples from poultry and humans.
  • Fecal samples were collected from both poultry and humans on broiler farms.
  • Metagenomics analysis was employed to examine the microbial composition and resistance genes.
  • The presence of common pathogens and resistance genes was investigated across the samples.
  • Poultry samples displayed greater microbial diversity compared to human samples.
  • Several pathogens were found to be shared between humans and poultry.
  • Multiple antimicrobial resistance genes were identified as common in both hosts.

Abstract

Indiscriminate use of over-the-counter antibiotics has led to the rapid emergence of resistant genes in bacteria, with the ultimate crisis to global health. One of the prominent sectors with the antimicrobial resistance (AMR) concern is the farm animals that exist in close contact with humans where the environmental conditions are favorable for the rapid dissemination of pathogenic organisms and resistance genes. Hence, to understand the threat with environmental AMR, a detailed molecular insight is very important. In this study, fecal samples from both poultry and associated humans were studied by metagenomics analysis. From the results, a primary understanding on the microbial diversity difference could be generated from the selected samples. Here, the poultry samples were identified to have more microbial diversity. At the same time, several pathogens were found to be shared commonly between the hosts. Upon detailed examination, several AMR genes were also observed to be common between the poultry and human samples. The results of the study are highly relevant in light of the "One Health" concept where an integrated approach is targeted.

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Cite This Study

Sreekumaran et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5122f03e14405aa9d6efhttps://doi.org/10.1177/15353141261449964
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