Rearrangement of myocytes by slippage along myocardial cleavage planes in the subendocardium accounts for >50% of normal systolic wall thickening.
Rearrangement of myocytes by slippage along myocardial cleavage planes accounts for a substantial proportion (> 50%) of normal systolic wall thickening in the subendocardium.
p-value: p=< .0005
Recent studies in humans and other species show that there is substantial transverse shear strain in the left ventricular myocardium, and others have shown transverse myocardial laminae separated by cleavage planes. We proposed that cellular rearrangement based on shearing along myocardial cleavage planes could account for > 50% of normal systolic wall thickening, since 50%) of systolic wall thickening. Furthermore, three-dimensional reconstruction of the myocardial laminae and local comparison with maximum strain vectors indicate that for the inner third of the ventricular wall the maximum shear deformation is a result of relative sliding between myocardial laminae.
LeGrice et al. (1995) studied Normal systolic wall thickening (n=8). Measurement of strains at two sites with different cleavage-plane anatomy vs. Anterior left ventricular wall vs septum was evaluated on Differences in cleavage-plane angle and systolic longitudinal-radial transverse shear (E23) at the two sites (p=< .0005). Rearrangement of myocytes by slippage along myocardial cleavage planes in the subendocardium accounts for >50% of normal systolic wall thickening.
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