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January 1, 1989Computer applications in the biosciences1,229 citations

Fast and sensitive multiple sequence alignments on a microcomputer

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DHDesmond G. HigginsPSPaul M. Sharp

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Abstract

A strategy is described for the rapid alignment of many long nucleic acid or protein sequences on a microcomputer. The program described can handle up to 100 sequences of 1200 residues each. The approach is based on progressively aligning sequences according to the branching order in an initial phylogenetic tree. The results obtained using the package appear to be as sensitive as those from any other available method.

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Cite This Study

Higgins et al. (1989) studied this question.

synapsesocial.com/papers/6a0deb46e51d8d6d0c09e1bfhttps://doi.org/10.1093/bioinformatics/5.2.151
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CLUSTAL: a package for performing multiple sequence alignment on a microcomputer1988 · 3,437 citations
  2. 2A general method applicable to the search for similarities in the amino acid sequence of two proteins1970 · 11,539 citations
  3. 3Multiple sequence alignment by a pairwise algorithm1987 · 74 citations
  4. 4A multiple sequence alignment program1986 · 157 citations
  5. 5A multiple alignment program for protein sequences1987 · 16 citations