Newly diagnosed type II diabetes was associated with significantly reduced vasoconstrictor responses in the toes (P<0.001) and fingers (P<0.05, P<0.01) compared to healthy matched controls.
Case-Control (n=98)
Do patients newly diagnosed with type II diabetes have impaired peripheral autonomic function compared to healthy controls?
Patients newly diagnosed with type II diabetes exhibit impaired peripheral autonomic function, as evidenced by reduced vasoconstrictor responses, even in the absence of detectable central cardiac autonomic impairment.
p-value: p=<0.001
OBJECTIVE: To measure both peripheral and central autonomic function in patients newly diagnosed with type II diabetes. RESEARCH DESIGN AND METHODS: Measurements were made on 49 diabetic patients (8 with long-standing diabetes and neuropathic complications, 41 with newly diagnosed type II diabetes) and on 49 healthy, age- and sex-matched, control subjects. Five of the 41 newly diagnosed type II diabetic patients had retinopathy, and 4 had clinical evidence of neuropathy. No patient or control subject had significant vascular disease. Cardiac autonomic function was investigated by using standard cardiovascular reflex tests. The digital vasoconstrictor responses to deep breathing and body cooling were measured using venous occlusion plethysmography. RESULTS: The vasoconstrictor responses to a deep breath and body cooling were significantly reduced (P < 0.001) in the fingers and toes of the neuropathic patients compared with their matched control subjects, as were the heart rate responses (P < 0.02). The vasoconstrictor responses were significantly reduced in the toes (P < 0.001) and fingers (P < 0.05, P < 0.01) of the newly diagnosed patients compared with the corresponding responses in the control subjects. There was no significant difference in the heart rate or blood pressure responses of these patients and control subjects during standard tests of cardiac autonomic function. CONCLUSIONS: Patients with type II diabetes may have impaired peripheral autonomic function at diagnosis.
McDaid et al. (1994) conducted a case-control in Type II Diabetes (n=98). Type II diabetes (exposure) vs. Healthy, age- and sex-matched control subjects was evaluated on Digital vasoconstrictor responses to deep breathing and body cooling (p=<0.001). Newly diagnosed type II diabetes was associated with significantly reduced vasoconstrictor responses in the toes (P<0.001) and fingers (P<0.05, P<0.01) compared to healthy matched controls.