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November 18, 2022Cardiac failure reviewOpen Access

Concomitant HFpEF and AF linked to substantially higher mortality, requiring integrated management of both conditions.

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Why the study?

Current management addresses HFpEF and AF separately without considering their joint impact on diagnosis, treatment, and prognosis, resulting in suboptimal outcomes and high mortality.

Population

Patients with concurrent heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF)

Design

Review

Key result

Concomitant heart failure with preserved ejection fraction and atrial fibrillation substantially increases mortality and requires a personalized, integrated management approach targeting both conditions.

Authors

OȚOtilia ȚicaWKWaseem KhambooDKDipak Kotecha

Discussion

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Overview

Integrated HFpEF-AF care may improve outcomes; leaves open optimal strategies pending prospective trials.

Structured PICO

P
Population
Patients with concurrent heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF)
I
Intervention
Integrated heart failure and AF management with parallel commencement and non-sequential uptitration of therapeutics

Restructuring care to integrate heart failure and AF teams with parallel therapeutic initiation is vital for improving outcomes in patients with concurrent HFpEF and AF.

Limitations

  • Diagnosis of HFpEF is challenging in the presence of AF
  • Conventional therapies often fail to improve clinical endpoints in this population
  • Lack of specific clinical trials for patients with both HFpEF and AF

Cite This Study

Țica et al. (2022) conducted a review in Heart failure with preserved ejection fraction (HFpEF) and Atrial Fibrillation (AF). Concomitant heart failure with preserved ejection fraction and atrial fibrillation substantially increases mortality and requires a personalized, integrated management approach targeting both conditions.

synapsesocial.com/papers/6a0ea47a53f874f2b22296dchttps://doi.org/10.15420/cfr.2022.03
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