Classical conditioning of immunosuppression using saccharin paired with cyclophosphamide significantly retarded the development of proteinuria and mortality in female New Zealand hybrid mice.
Does classical conditioning of immunosuppression reduce the development of proteinuria and mortality in female New Zealand hybrid mice with systemic lupus erythematosus?
Classical conditioning of immunosuppression using saccharin and cyclophosphamide significantly retards the development of autoimmune disease (proteinuria and mortality) in a murine model of systemic lupus erythematosus.
Development of autoimmune disease in female New Zealand hybrid mice was dramatically modified by classical conditioning of immunosuppression. Groups of animals received each week a solution of sodium saccharin (conditioned stimulus). One group of conditioned animals received an injection of cyclophosphamide (the unconditioned stimulus) after half of the weekly occasions when they received the saccharin solution. The rate of development of proteinuria and mortality were significantly retarded in these conditioned mice relative to untreated controls and nonconditioned animals that received unpaired treatment with saccharin and cyclophosphamide.
Ader et al. (1982) studied Systemic Lupus Erythematosus. Classical conditioning of immunosuppression (sodium saccharin paired with cyclophosphamide) vs. Untreated controls and nonconditioned animals (unpaired treatment) was evaluated on Rate of development of proteinuria and mortality. Classical conditioning of immunosuppression using saccharin paired with cyclophosphamide significantly retarded the development of proteinuria and mortality in female New Zealand hybrid mice.