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The analytical, within-subject and between-subject components of variation were estimated for serum albumin, transthyretin, α 1 -acid glycoprotein, α 1 -antichymotrypsin, haptoglobin, β 2 -microglobulin and C-reactive protein in a cohort of 19 apparently healthy subjects over 20 weeks. Desirable analytical goals based on biological variation should be able to be met except for serum albumin and β 2 -microglobulin for which methodological improvement is warranted. All proteins showed marked individuality which casts doubt on the utility of conventional population-based reference values as interpretative criteria. The critical differences required for significance of changes in serial results differ markedly from protein to protein and the data presented allow generation of objective criteria for monitoring individuals.
Clark et al. (1993) studied this question.