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November 1, 1990Annual Review of Cell Biology604 citations

Cell Biology of von Willebrand Factor

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DWDD Wagner

Key Points

  • Review the cell biology, domain architecture, and biosynthetic pathway of von Willebrand factor.
  • Synthesized molecular and cell biological findings on von Willebrand factor domain organization.
  • Evaluated intracellular transport and maturation steps spanning the endoplasmic reticulum and Golgi compartments.
  • Outlines the domain structure required for von Willebrand factor stability and multimerization.
  • Details the sequential biosynthesis and modification of the protein within the endoplasmic reticulum and post-Golgi secretory pathways.

Abstract

vWF DOMAIN STRUCTURE 219 vWF BIOSYNTHESIS •• , . . ,' 222 Endoplasmic Reticulum.,', .... ,',., . . ..,. 224 Golgi and Post-Golgi Compartments,.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,. 225

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Cite This Study

DD Wagner (1990) studied this question.

synapsesocial.com/papers/6a0eeda753f874f2b222f57bhttps://doi.org/10.1146/annurev.cb.06.110190.001245
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