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March 5, 1973JAMA269 citations

Prognostic Importance of Premature Beats Following Myocardial Infarction

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Key Result

The presence of ventricular premature beats on a resting baseline ECG in survivors of myocardial infarction was associated with increased 3-year mortality compared to no VPB (21.7% vs 11.4%).

Key Points

  • To evaluate the prognostic significance of ventricular premature beats (VPB) in survivors of myocardial infarction.
  • Analyzed the electrocardiograms of 2,035 myocardial infarction survivors to identify VPB presence.
  • Conducted a three-year follow-up to track death rates among patients with and without VPB.
  • Focused on mortality relative to VPB frequency and patterns.
  • Mortality rate among patients with VPB was 21.7% compared to 11.4% for those without VPB (p<0.001).
  • High VPB frequency (in pairs or runs) was independently associated with increased risk of death.
  • The risk increase was consistent regardless of other electrocardiographic and clinical variables.

Study Design

Type

Cohort (n=2,035)

Multicenter

Yes

Structured PICO

Does the presence of ventricular premature beats on baseline ECG increase the risk of death in male survivors of myocardial infarction?

P
Population
2,035 male survivors of myocardial infarction (placebo-treated patients in the nationwide Coronary Drug Project)
I
Intervention
Presence of one or more ventricular premature beats (VPB) in resting baseline electrocardiogram
C
Comparator
Absence of ventricular premature beats (VPB) in resting baseline electrocardiogram
O
Outcome
Death (long-term risk of death, including sudden death)hard clinical

The presence and frequency of ventricular premature beats on a resting baseline ECG independently predict an increased long-term risk of death in male survivors of myocardial infarction.

Main Result

Absolute Event Rate: 21.7% vs 11.4%

Abstract

Two hundred thirty-five men among 2,035 survivors of myocardial infarction (11.5%) had one or more ventricular premature beats (VPB) in their resting base-line electrocardiogram. During a three-year follow-up period, deaths were about twice as frequent in those with any VPB (21.7%) as in those with none (11.4%) among the placebo-treated patients in the nationwide Coronary Drug Project. Excess long-term risk of death, including sudden death, was associated with the frequency of VPB, with VPB in pairs or runs, and possibly with early-cycle VPB. The excess risk with these VPB characteristics was independent of the risk associated with other electrocardiographic and clinical characteristics.

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Cite This Study

A 1973 study conducted a cohort in Myocardial infarction (n=2,035). Ventricular premature beats (VPB) vs. No VPB was evaluated on Death. The presence of ventricular premature beats on a resting baseline ECG in survivors of myocardial infarction was associated with increased 3-year mortality compared to no VPB (21.7% vs 11.4%).

synapsesocial.com/papers/6a0efeb8a14f152feafa2061https://doi.org/10.1001/jama.1973.03220100016005
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