Monophasic action potential duration alternans was observed in 6.6% (3 of 45) of patients with persistent atrial fibrillation during rapid ventricular pacing.
Observational (n=45)
Does rapid ventricular pacing induce monophasic action potential duration alternans in patients with persistent atrial fibrillation?
Action potential alternans is observed in 6.6% of humans during rapid ventricular pacing, suggesting it is not a rare phenomenon and may be relevant to ventricular arrhythmias.
Abstract Background Action potential alternans may be important in causing ventricular arrhythmias. Methods and results We recorded monophasic action potentials from the right ventricular endocardium in patients with persistent atrial fibrillation who underwent internal atrial defibrillation during rapid ventricular pacing. In 3 of 45 patients, monophasic action potential duration alternans was observed at a pacing cycle length ≤350 ms. Conclusion Action potential alternans is not a rare phenomenon (6.6%) in humans.
Sonoda et al. (2013) conducted an observational in Persistent atrial fibrillation (n=45). Rapid ventricular pacing was evaluated on Monophasic action potential duration alternans at a pacing cycle length ≤350 ms. Monophasic action potential duration alternans was observed in 6.6% (3 of 45) of patients with persistent atrial fibrillation during rapid ventricular pacing.