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June 18, 2008New England Journal of Medicine907 citationsOpen Access

Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1

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NHNaomi HunderHWHerschel WallenJCJianhong Cao

Key Points

  • This research aims to evaluate the efficacy of autologous CD4+ T cells targeting NY-ESO-1 in treating metastatic melanoma.
  • Isolated and expanded autologous CD4+ T-cell clones targeting NY-ESO-1.
  • Infused CD4+ T cells into a patient with refractory metastatic melanoma without previous treatment.
  • Monitored clinical outcomes and responses to additional melanoma antigens.
  • The infusion led to sustained clinical remission in the patient.
  • Endogenous immune responses were detected against other melanoma antigens beyond NY-ESO-1.
  • No previous conditioning or cytokine treatment was administered before the infusion.

Abstract

We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.

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Cite This Study

Hunder et al. (2008) studied this question.

synapsesocial.com/papers/6a0f7addfa36b6e053fcb67ehttps://doi.org/10.1056/nejmoa0800251
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