Preoperative right ventricular end-systolic volume >95 mL/m2 increased the risk of adverse clinical events after pulmonary valve replacement in tetralogy of Fallot (HR 2.89; 95% CI 1.03-8.11).
Cohort (n=157)
Yes
What are the optimal preoperative right ventricular volume thresholds to achieve mid-to-late RV normalization and prevent adverse clinical events after pulmonary valve replacement in patients with tetralogy of Fallot?
In patients with tetralogy of Fallot undergoing pulmonary valve replacement, a preoperative RV ESV < 80 mL/m² optimizes mid-to-late RV normalization, while a threshold > 95 mL/m² significantly increases the risk of adverse clinical events.
Effect estimate: HR 2.89 (95% CI 1.03-8.11)
AIMS: The right ventricle (RV) remodels early after pulmonary valve replacement (PVR) in tetralogy of Fallot (TOF) patients. Previously reported preoperative thresholds to achieve early postoperative RV normalization were consistently close to 80 mL/m(2) for end-systolic volume (ESV) and 160 mL/m(2) for end-diastolic volume (EDV). Our objective was to determine whether these thresholds were also associated with mid-to-late RV normalization and clinical events. METHODS AND RESULTS: Out of a multicentre cohort of 157 TOF patients who had undergone PVR, in 65 patients (62% male, age 29 ± 8 years, homograft in 98%) cardiovascular magnetic resonance (CMR) imaging was performed preoperatively and >3 years (6.3 years, interquartile range: 4.9-9.5) postoperatively. Mid-to-late haemodynamic outcome was classified as: 'RV normalization' [RV ejection fraction (EF) > 48% and RV EDV 120 mL/m(2)) in 17 of 65 (26%) patients. Preoperative RV ESV 95 mL/m(2) were at increased risk for unfavourable mid-to-late haemodynamic outcome (common OR: 25.5, 95% CI: 5.35-122) and events (hazard ratio: 2.89, 95% CI: 1.03-8.11). CONCLUSION: In TOF patients who had undergone PVR, the best preoperative threshold to achieve mid-to-late RV normalization was RV ESV 95 mL/m(2) were at increased risk for suboptimal haemodynamic outcome and adverse clinical events. Our findings may assist in timing of PVR.
Bokma et al. (2015) conducted a cohort in Tetralogy of Fallot (n=157). Preoperative right ventricular end-systolic volume > 95 mL/m2 was evaluated on Adverse clinical events (death, sustained ventricular tachycardia, or heart failure) (HR 2.89, 95% CI 1.03-8.11). Preoperative right ventricular end-systolic volume >95 mL/m2 increased the risk of adverse clinical events after pulmonary valve replacement in tetralogy of Fallot (HR 2.89; 95% CI 1.03-8.11).