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May 22, 2026Computer Methods in Biomechanics & Biomedical Engineering1 citations

A synergistic framework for hemodynamics within eccentric vascular constrictions

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AHAzad HussainAHArslan Hassan

Key Result

Simulations of blood flow in stenosed arteries under severe pathological conditions revealed critical flow dampening with peak axial velocities of 0.14-0.22 m/s and a 15,400 Pa pressure drop.

Key Points

  • The aim is to explore how hemodynamics interact within eccentric vascular constrictions.
  • Developed a mathematical model to analyze blood flow dynamics.
  • Simulated different levels of vascular constriction.
  • Assessed the impact on pressure gradients and flow rates.
  • Notable changes in blood flow patterns were observed at varying constriction levels.
  • Higher pressure gradients were linked to increased flow disturbances.
  • Findings indicate potential risk factors for vascular complications.

Structured PICO

P
Population
Computational model of tilted ellipsoidal stenosed arteries
E
Exposure
Modeling blood as a non-Newtonian fluid via the Carreau model
C
Comparator
Homotopy Perturbation Method (for validation)
O
Outcome
Impact of zero shear rate viscosity and relaxation time on flow fields (peak axial velocities, pressure drop)surrogate

Advanced rheological models using the Carreau model demonstrate significant flow dampening and pressure drops in severe arterial stenosis, highlighting their importance for accurate arterial disease prediction.

Abstract

This study analyzes blood flow hemodynamics within tilted ellipsoidal stenosed arteries. Modeling blood as a non-Newtonian fluid via the Carreau model, we evaluate the impact of zero shear rate viscosity and relaxation time on flow fields. Solutions obtained using the finite element method in COMSOL Multiphysics are validated against the Homotopy Perturbation Method. Simulations under severe pathological conditions (μ0 = 0.076 Pa·s) reveal critical flow dampening, with peak axial velocities of 0.14-0.22 m/s. This disturbed flow causes a substantial 15,400 Pa pressure drop. The findings highlight the necessity of advanced rheological models for accurate arterial disease prediction.

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Cite This Study

Hussain et al. (2026) studied Stenosed arteries. Severe pathological conditions (μ0 = 0.076 Pa·s) was evaluated on Flow fields, peak axial velocities, and pressure drop. Simulations of blood flow in stenosed arteries under severe pathological conditions revealed critical flow dampening with peak axial velocities of 0.14-0.22 m/s and a 15,400 Pa pressure drop.

synapsesocial.com/papers/6a0ff780d674f7c03778dc78https://doi.org/10.1080/10255842.2026.2672038
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