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The major features of multiple myeloma have been reviewed recently by Bayrd and Heck'5 and Lichtenstein and Jaffe.'6 It is a uniformly malignant disease progressing to a fatal termination in an interval varying from a few weeks to sometimes several years. The disease results essentially from the excessive proliferation of abnormal plasma or ' ' myeloma' ' cells within the bone marrow. Anemia, leukopenia and at times thrombocytopenia result. Skeletal support becomes seriously impaired as the bones soften due to diffuse demineralization or to the formation of multiple areas of osseous destruction showing virtually no detectable LOGE AND
LOGE et al. (1949) studied this question.