A single oral loading dose of amiodarone achieved a 64.4% conversion rate to sinus rhythm at 24 hours, comparable to 66.7% with intravenous amiodarone in patients with atrial tachyarrhythmia.
Observational (n=72)
Does a single oral loading dose of amiodarone improve conversion to sinus rhythm compared to intravenous amiodarone in patients with recent-onset sustained atrial tachyarrhythmia?
A single oral loading dose of amiodarone provides a similar rate of conversion to sinus rhythm at 24 hours compared to intravenous amiodarone in patients with recent-onset atrial tachyarrhythmia, with potentially fewer minor adverse effects.
Absolute Event Rate: 64.4% vs 66.7%
Forty-five patients with recent-onset sustained atrial tachyarrhythmia (mean heart rate at entry; 140.0 +/- 3.5 beats.min-1) associated with various cardiovascular diseases were treated by oral amiodarone, given as a single loading dose of 25.7 +/- 0.9 mg.kg-1 body weight. Conversion to sinus rhythm was observed in 29 patients during the first 24 h of treatment, leading to a success rate of 64.4%. Five additional patients converted to sinus rhythm with continuation of oral amiodarone, (10-15 mg.kg-1 by day) with a mean delay of 4.2 days. A similar population of 27 patients (mean heart rate at entry; 140 +/- 3 beats.min-1) was treated by intravenous amiodarone, given as a bolus infusion of 3-5 mg.kg-1 over 30 min (mean; 4.1 +/- 0.2 mg.kg-1), followed by a continuous infusion of 10-15 mg.kg-1 for 24 h (mean; 11.1 +/- 0.7 mg.kg-1). Eighteen patients converted to sinus rhythm during the first 24 h of therapy, leading to a success rate of 66.7%. Minor adverse effects of therapy were observed in two patients given oral amiodarone, and in seven given intravenous amiodarone. No major effect was observed. We suggest that amiodarone given as a single oral loading dose of 25-30 mg.kg-1 body weight is an effective, simple and well-tolerated therapy, suitable for most patients with recent-onset ATA.
Andrivet et al. (Sat,) conducted a observational in recent-onset sustained atrial tachyarrhythmia (n=72). Oral amiodarone vs. Intravenous amiodarone was evaluated on Conversion to sinus rhythm during the first 24 h. A single oral loading dose of amiodarone achieved a 64.4% conversion rate to sinus rhythm at 24 hours, comparable to 66.7% with intravenous amiodarone in patients with atrial tachyarrhythmia.
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