Higher coronary artery calcium scores were significantly associated with increased age-adjusted rates of hard CHD events in both asymptomatic men (trend p<0.0001) and women (trend p=0.02).
Cohort (n=10,746)
No
Does coronary artery calcium (CAC) score predict coronary heart disease events in asymptomatic adults?
Coronary artery calcium (CAC) score is significantly and independently associated with an increased risk of hard and total coronary heart disease events in asymptomatic men and women.
p-value: p=<0.0001
Coronary artery calcium (CAC), a measure of subclinical coronary heart disease (CHD), may be useful in identifying asymptomatic persons at risk of CHD events. The current study included 10,746 adults who were 22-96 years of age, were free of known CHD, and had their CAC quantified by electron-beam tomography at baseline as part of a preventive medical examination at the Cooper Clinic (Dallas, Texas) during 1995-2000. During a mean follow-up of 3.5 years, 81 hard events (CHD death, nonfatal myocardial infarction) and 287 total events (hard events plus coronary revascularization) occurred. Age-adjusted rates (per 1,000 person-years) of hard events were computed according to four CAC categories: no detectable CAC and incremental sex-specific thirds of detectable CAC; these rates were, respectively, 0.4, 1.5, 4.8, and 8.7 (trend p65 years) study participants. These findings show that CAC is associated with an increased risk of CHD events in asymptomatic women and men.
LaMonte et al. (2005) conducted a cohort in Asymptomatic persons free of known CHD (n=10,746). Coronary artery calcium (CAC) quantification vs. No detectable CAC was evaluated on Hard events (CHD death, nonfatal myocardial infarction) (p=<0.0001). Higher coronary artery calcium scores were significantly associated with increased age-adjusted rates of hard CHD events in both asymptomatic men (trend p<0.0001) and women (trend p=0.02).