Burnout cases overall did not differ significantly from healthy controls in insulin resistance (HOMA-IR 1.40 vs 1.57) or glucose levels during an oral glucose tolerance test.
Cross-Sectional (n=73)
No
Do individuals with stress-related burnout exhibit altered glucose and insulin levels during an oral glucose tolerance test compared to healthy controls?
Severe burnout and depressive symptoms are associated with higher glucose and insulin levels during an OGTT, indicating a potential increased risk for type 2 diabetes.
Absolute Event Rate: 1.4% vs 1.57%
p-value: p=0.592
Burnout is caused by long term psychosocial stress and has, besides the fatigue and mental health burden, been associated with increased risk of adverse physical health, such as for example type 2 diabetes. This study aims to investigate the glucose and insulin levels in individuals with stress related burnout, by assessing these metabolic markers in response to a standard oral glucose tolerance test (OGTT). 38 cases with burnout (13 men and 25 women) and 35 healthy controls (13 men and 22 women) in the age 24-55 were included in the study. The burnout group overall did not differ from healthy controls in glucose or insulin levels during the OGTT. However, the burnout cases who reported more severe burnout symptoms exhibited significantly higher levels of both glucose and insulin levels during the OGTT compared to burnout cases reporting lower severity of symptoms. Furthermore, the group of burnout cases who reported symptoms of depression exhibited higher insulin levels during OGTT compared to the burnout cases without depressive symptoms. The observed higher levels in the burnout cases with most severe symptoms indicate an increased diabetic risk in these patients and it may be of importance to follow glucose and insulin levels in individuals with more severe symptoms of burnout i.e. to perform an OGTT.
Lennartsson et al. (2024) conducted a cross-sectional in Burnout (n=73). Burnout vs. Healthy controls was evaluated on HOMA-IR (insulin resistance) (p=0.592). Burnout cases overall did not differ significantly from healthy controls in insulin resistance (HOMA-IR 1.40 vs 1.57) or glucose levels during an oral glucose tolerance test.
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