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June 1, 1980Cancer177 citationsOpen Access

The earlier detection of colorectal cancers. A preliminary report of the results of the occult blood study

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VGVictor A. GilbertsenRMRichard McHughLSLeonard M. Schuman

Key Points

  • To assess the effectiveness of occult stool blood testing in the early detection of colorectal cancers.
  • Long-term clinical study with 48,000 participants enrolled.
  • Examination of 873 patients with detected occult stool blood.
  • Data collection includes control group comparisons once available.
  • 77 gastrointestinal cancers found in 74 patients with occult stool blood.
  • Conventional barium-enema missed one third of colon cancers and two-thirds of colon polyps identified via colonoscopy.
  • Preliminary results suggest many of the detected cancers are in early stages.

Abstract

A long-term clinical study is underway to evaluate the merit of occult stool blood testing in the earlier detection of colorectal cancers; 48,000 participants have been enrolled. Thus far, 873 patients with occult stool blood have been examined, and 77 gastrointestinal cancers have been found in 74 patients. Although data from the control group are not yet available for comparison, most of the cancers found appear to be relatively early in their development. Conventional barium-enema examinations were noted to have "missed" one third of the colon cancers and two-thirds of the colon polyps which were found on colonoscopy. Preliminary results of the study appear encouraging. Definitive analysis will await the availability of additional pertinent data.

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Cite This Study

Gilbertsen et al. (1980) studied this question.

synapsesocial.com/papers/6a11d84002d9c5b08421a4e5https://doi.org/10.1002/1097-0142(19800601)45:11<2899::aid-cncr2820451132>3.0.co;2-m
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Colorectal cancer screening; colonoscopy and biopsy results in people undergoing colonoscopy due to positive fecal occult blood test2024 · 2 citations
  2. 2Faecal occult blood testing: a review of its use and common misutilisation.2025
  3. 3Effectiveness of colonoscopy, immune fecal occult blood testing, and risk-graded screening strategies in colorectal cancer screening2024 · 1 citations
  4. 4Understanding the Utility of Fecal Occult Blood Testing in Hospitalized Patients With Suspected GI Bleeding2024
  5. 5Colonoscopy Versus Fecal Occult Blood Test Versus No Screening: A Comparative Analysis of Long-Term Effects.2026