Higher carotid-femoral pulse wave velocity was associated with an increased risk of cardiovascular events (RR 1.25 per 1 SD increase; 95% CI 1.19-1.31) and cardiovascular mortality.
Meta-Analysis
Does high carotid-femoral pulse wave velocity (cf-PWV) predict clinical CVD events and CVD mortality?
Carotid-femoral pulse wave velocity is a useful biomarker that significantly predicts cardiovascular events and mortality, particularly in high-risk patients.
Effect estimate: RR 1.25 (95% CI 1.19-1.31)
Arterial stiffness (AS) is a predictor of coronary artery outcomes in patients with cardiovascular disease (CVD). Carotid-femoral pulse wave velocity (cf-PWV) is a commonly used method for assessing AS. This study aimed to assess the relationship between cf-PWV and clinical CVD events. Of the 786 studies identified, 19 studies were included in the final meta-analysis. Meta-analysis revealed that participants with high cf-PWV by 1 standard deviation (SD), 1 m/s, and cutoff points have a high pooled relative risk for CVD events (1 SD: 1.25, 95% confidence interval CI: 1.19-1.31; 1 m/s: 1.12, 95% CI: 1.07-1.18; and cutoff points: 1.80, 95% CI: 1.45-2.14) and CVD mortality (1 SD: 1.23, 95% CI: 1.15-1.31; 1 m/s: 1.09, 95% CI: 1.04-1.14; and cutoff points: 1.85, 95% CI: 1.46-2.24). In addition, we found that the predictive value of increased AS was higher in patients with higher disease risk for total CVD events and CVD mortality than in other patients. Carotid-femoral pulse wave velocity is a useful biomarker to improve the prediction of CV risk for patients and identify high-risk populations who may benefit from aggressive CV risk factor management.
Zhong et al. (2017) conducted a meta-analysis in Cardiovascular disease. Carotid-femoral pulse wave velocity (cf-PWV) was evaluated on CVD events (RR 1.25, 95% CI 1.19-1.31). Higher carotid-femoral pulse wave velocity was associated with an increased risk of cardiovascular events (RR 1.25 per 1 SD increase; 95% CI 1.19-1.31) and cardiovascular mortality.