Does amiodarone increase plasma digoxin concentrations in patients receiving maintenance digoxin treatment?
Co-administration of amiodarone in patients on maintenance digoxin increases plasma digoxin levels and the risk of toxicity.
As treatment regimens become more complex the dangers of drug interaction increase. We observed that several patients receiving maintenance digoxin treatment abruptly developed clinical evidence of toxicity when amiodarone, a newly available antiarrhythmic agent, was administered in addition. We therefore studied several patients to determine the response of plasma digoxin concentrations to treatment with amiodarone.
Moysey et al. (1981) studied this question.