Does sleep-related breathing disorder severity increase the risk of systemic hypertension in patients referred for SRBD diagnosis?
Sleep-related breathing disorder severity is independently associated with higher daytime blood pressure and an increased risk of systemic hypertension, particularly in younger patients.
The exact influence of sleep-related breathing disorder (SRBD) on blood pressure control remains unknown. We investigated the influence of different degrees of SRBD on daytime blood pressure and its association to documented hypertension by examining 1,190 consecutive patients referred for diagnosis of SRBD. The protocol includes clinical interview, physical examination, office blood pressure measurement, cholesterol, and blood gas analysis. Unattended home monitoring of nocturnal breathing was performed for assessment of SRBD activity (respiratory disturbance index RDI). RDI was independently and linearly associated with systolic blood pressure (unstandardized coefficient B = 0.07 +/- 0.03, p = 0.03), diastolic blood pressure (B = 0.07 +/- 0.02, p = 0 /= 160/95 mm Hg) increased with SRBD severity (odds ratio OR, 4.15 for RDI >/= 40 versus 50 yr) (OR, 7.15 versus 2.70 for RDI >/= 40 versus < 5). These cross-sectional clinical data suggest a relationship between SRBD severity and systolic blood pressure, diastolic blood pressure, and heart rate after control for confounders such as body mass index (BMI), age, alcohol/nicotine consumption, cholesterol level, and daytime PO(2) and PCO(2). SRBD is an independent risk factor for systemic hypertension with an increased likelihood in subjects </= 50 yr of age.
Grote et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: