Why the study?
Does the dexamethasone suppression test predict treatment response or outcome in patients with major depression?
Population
Patients with major depression from 144 articles
Comparison
Dexamethasone suppression test vs Normal cortisol suppression (suppressors)
Design
Meta-analysis
Key result
Posttreatment nonsuppression of cortisol on the dexamethasone suppression test is strongly associated with poor outcome and high risk of early relapse in major depression.
Authors
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May inform posttreatment risk stratification in major depression; confirms DST prognostic utility beyond baseline.
Meta-Analysis
Does the dexamethasone suppression test predict treatment response or outcome in patients with major depression?
While baseline DST results lack prognostic value, persistent nonsuppression of cortisol post-treatment strongly predicts poor outcome and early relapse in major depression.
Ribeiro et al. (1993) conducted a meta-analysis in Major depression. Dexamethasone suppression test (DST) was evaluated on Treatment response or outcome after hospital discharge. Posttreatment nonsuppression of cortisol on the dexamethasone suppression test is strongly associated with poor outcome and high risk of early relapse in major depression.