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May 25, 2026International Journal of Hepatology0 citationsOpen Access

LC‐Pred: A Transformer‐Based Interactive Interface for Liver Cirrhosis Prediction

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BRBisweswari RathSDSatya Ranjan DashRMRajani Kanta Mahapatra

Key Points

  • This study aims to develop and assess LC-Pred, a web application designed for the early prediction of liver cirrhosis using advanced AI techniques.
  • Utilized data from 1098 real-time patients including cases of liver cirrhosis and non-liver cirrhosis.
  • Implemented and compared traditional scoring systems with AI-based models using 20 clinical parameters including age and gender.
  • Developed a web application with features such as authentication and PDF report generation for efficient clinical use.
  • Transformer model achieved a precision recall area under the curve (PR-AUC) of 0.907 and a receiver operating characteristics area under the curve (ROC-AUC) of 0.989.
  • Sensitivity for liver cirrhosis detection was 0.857, while specificity for non-liver cirrhosis prediction was 0.947.
  • Overall test accuracy of the model was 0.977 with a Brier score of 0.027.

Abstract

Objectives Incorporating transformer, an innovative deep learning–based model with an authenticated and user‐friendly client‐server web application namely LC‐Pred, this study highlights the early prediction of liver cirrhosis (LC), which will be beneficial for both the clinicians and the LC patients. LC‐Pred delivers both single and bulk prediction abilities making it fast, sturdy, and secure to be used in healthcare sectors. Methods This study uses a total of 1098 real‐time patients′ data having both LC and nonliver cirrhosis (NLC) cases to implement and compare traditional scoring systems and AI‐based models, by using 20 clinical parameters with two demographic data such as patients′ age and gender. Results The tool consists of authentication, PDF report generation and spontaneous interface elevated for clinical workflow incorporation. Transformer model exhibits the highest accuracy among all the traditional and artificial intelligence (AI) models and is selected to be linked with LC‐Pred for classification of cirrhosis. Transformer model accomplishes a vigorous performance with precision recall area under the curve (PR‐AUC) of 0.907, receiver operating characteristics area under the curve (ROC‐AUC) of 0.989, sensitivity/recall of 0.857 (for LC detection) and specificity of 0.947 (for NLC prediction), Brier score is of 0.027 and test accuracy of 0.977. Conclusion The tool exhibits noteworthy upgradation in AI‐assisted hepatology, over traditional scoring techniques like model for end‐stage liver disease (MELD) and Child–Pugh, by stabilizing the technical intricacy with clinical efficacy. This note delineates the application framework, model training principles, evaluating results and the importance of implementing an aligned AI system to be utilized by the clinicians.

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Cite This Study

Rath et al. (2026) studied this question.

synapsesocial.com/papers/6a13e7a80e02ee3982d325e6https://doi.org/10.1155/ijh/3655128
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