Purpose: The frequency of nonalcolic fatty liver disease (NAFLD), a major health issue that affects people all over the world, has been rising recently. Numerous studies have demonstrated the tight connection between NAFLD and thyroid function. In this study, we aimed to evaluate the relationship between thyroid function tests and the degree of liver steatosis in patients with biopsy proven NAFLD. Patients and Methods: We retrospectively evaluated data of living donor applicants who received liver biopsies. Three hundred sixty seven patients were included in the study. According to the liver biopsy results, the patients were divided into two groups; 227 patients biopsy-proven NAFLD and 145 control subjects without NAFLD. Demographic, anthropometric and laboratory parameters were compared between two groups. Results: All groups thyroid function tests fall within the normal range. However, in patients with NAFLD, serum FT3 and FT4 levels were significantly higher than control group. In addition negative relationship was found between the levels of FT3, FT4, and the stage of NAFLD. In patients with NAFLD, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, triglyceride, total cholesterol levels, homeostasis model assessment of insulin resistance (HOMA-IR), body mass index were significantly high. Conclusion: In this retrospective study, we showed that in patients with NAFLD, serum FT3 and FT4 levels were significantly lower than the control group. Our findings support that low levels of serum FT3 and FT4 might be a risk factor for liver steatosis in euthyroid patients with NAFLD. Keywords: nonalcolic fatty liver disease, thyroid function, hepatic steatosis
Oral et al. (2026) studied this question.