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October 1, 2020Scientific Reports37 citationsOpen Access

Automatic classification of healthy and disease conditions from images or digital standard 12-lead electrocardiograms

ВГВадим ГлинерNKNoam KeidarVMVladimir Makarov

Key Result

Deep convolutional neural networks identified eight common cardiac conditions from digital 12-lead ECGs with 92.9-100% accuracy and detected atrial fibrillation from ECG images with 96% accuracy.

Structured PICO

Do deep convolutional neural networks accurately classify healthy and disease conditions from digital and image-based standard 12-lead ECGs?

P
Population
41,830 standard 12-lead ECG recordings from 6,866 patients and volunteers (3,174 female; 3,692 male) collected across 11 hospitals.
I
Intervention
Deep convolutional neural networks (CNN-dig for digital signals and CNN-ima for images) trained to automatically classify 12-lead ECGs.
C
Comparator
Ground truth classification by board-certified practicing cardiologists.
O
Outcome
Diagnostic accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and F1 score for detecting normal sinus rhythm and 8 cardiac conditions (AF, I-AVB, LBBB, RBBB, PAC, PVC, STD, STE).surrogate

Automated detection of multiple cardiac conditions using deep learning on standard digital or smartphone-imaged 12-lead ECGs is highly accurate and feasible.

Limitations

  • Construction of an algorithm for rendering ECG images instead of using real images, which may not capture real-world artifacts.
  • Inability to indicate how different features of the ECG contributed to the final network output due to the complex nature of neural networks.

Abstract

Standard 12-lead electrocardiography (ECG) is used as the primary clinical tool to diagnose changes in heart function. The value of automated 12-lead ECG diagnostic approaches lies in their ability to screen the general population and to provide a second opinion for doctors. Yet, the clinical utility of automated ECG interpretations remains limited. We introduce a two-way approach to an automated cardiac disease identification system using standard digital or image 12-lead ECG recordings. Two different network architectures, one trained using digital signals (CNN-dig) and one trained using images (CNN-ima), were generated. An open-source dataset of 41,830 classified standard ECG recordings from patients and volunteers was generated. CNN-ima was trained to identify atrial fibrillation (AF) using 12-lead ECG digital signals and images that were also transformed to mimic mobile device camera-acquired ECG plot snapshots. CNN-dig accurately (92.9-100%) identified every possible combination of the eight most-common cardiac conditions. Both CNN-dig and CNN-ima accurately (98%) detected AF from standard 12-lead ECG digital signals and images, respectively. Similar classification accuracy was achieved with images containing smartphone camera acquisition artifacts. Automated detection of cardiac conditions in standard digital or image 12-lead ECG signals is feasible and may improve current diagnostic methods.

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Cite This Study

Глинер et al. (2020) studied Cardiac arrhythmias and morphological disorders (n=6,866). Deep convolutional neural networks (CNN-dig and CNN-ima) vs. Board-certified practicing cardiologists (ground truth) was evaluated on Classification accuracy for cardiac conditions. Deep convolutional neural networks identified eight common cardiac conditions from digital 12-lead ECGs with 92.9-100% accuracy and detected atrial fibrillation from ECG images with 96% accuracy.

synapsesocial.com/papers/6a14d23615979a09e162daa4https://doi.org/10.1038/s41598-020-73060-w
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