A high C-reactive protein to albumin ratio was associated with a 2.26-fold increased risk of all-cause mortality compared to a low ratio in patients with chronic total occlusion undergoing PCI.
Cohort (n=664)
No
Does a higher C-reactive protein to albumin ratio predict increased risk of adverse cardiovascular events in patients with chronic total occlusion undergoing percutaneous coronary intervention?
The C-reactive protein to albumin ratio is a significant independent predictor of all-cause and cardiovascular mortality in patients undergoing PCI for chronic total occlusion, improving traditional risk prediction models.
Effect estimate: HR 2.26 (95% CI 1.06-4.79)
Absolute Event Rate: 16.3% vs 5.9%
p-value: p=0.034
Inflammation and nutrition as main factors can affect the prognosis of patients with chronic total coronary occlusion (CTO) undergoing percutaneous coronary intervention (PCI). The C-reactive protein to albumin ratio (CAR) can clarify the inflammation and nutrition status, which are highly related to clinical outcomes. This study aims to investigate the association between CAR and adverse cardiovascular events in patients with CTO undergoing PCI. For this study, 664 patients were divided into three groups based on the tertiles of CAR. The primary endpoint was all-cause mortality and the secondary endpoint was major adverse cardiovascular events (MACE). Over a median follow-up of 33.7 months, the primary endpoint occurred in 64 patients (9.6%) and the secondary endpoint occurred in 170 patients (25.6%). The patients with higher CAR represented a worse prognosis with all-cause death and cardiovascular death after the adjustment for the baseline risk factors. Adding the CAR values raised the predictive value for the incidence of the all-cause death and cardiovascular death but not MACE. The capacity of prognosis prediction was improved after the addition of the CAR value to the traditional prediction model.
Cheng et al. (2021) conducted a cohort in Chronic total coronary occlusion (CTO) undergoing percutaneous coronary intervention (PCI) (n=664). High C-reactive protein to albumin ratio (CAR-H) vs. Low C-reactive protein to albumin ratio (CAR-L) was evaluated on All-cause mortality (HR 2.26, 95% CI 1.06-4.79, p=0.034). A high C-reactive protein to albumin ratio was associated with a 2.26-fold increased risk of all-cause mortality compared to a low ratio in patients with chronic total occlusion undergoing PCI.