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May 26, 2026Materials & Design0 citationsOpen Access

FeSO4-Vitamin C co-loaded active targeting liposome inhibits liver cancer through synergistic ferroptosis mechanism

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HYHao YangHHHui HouHLHui Li

Key Points

  • The study aims to evaluate the synergistic effects of FeSO4 and Vitamin C co-loaded liposomes on liver cancer via ferroptosis mechanisms.
  • Developed a liposome formulation integrating Fe2+ and Vitamin C for enhanced targeting.
  • Evaluated the oxidative stress response and ferroptosis in liver cancer cell lines using the new formulation.
  • Increased intracellular delivery of Fe2+ and Vitamin C was observed, leading to elevated oxidative stress levels.
  • Enhanced liver cancer cell death was noted due to the synergistic effect of Fe2+ and Vitamin C, promoting ferroptosis.

Abstract

• Vc maintains the stability of Fe 2+ during storage. • High concentrations of Fe 2+ and Vc within cells exert a synergistic effect in amplifying ferroptosis-associated oxidative stress • Fe-Vc-LIP-Gal integrates the passive and active tumor targeting, which can significantly enhance the intracellular delivery efficiency of Fe 2+ and Vc.

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Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a1538ebb5d9c58d83e8c8fbhttps://doi.org/10.1016/j.matdes.2026.116283
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