The Cardiac Morphogenic Supremacy Theorem is proposed to theoretically explain the heart's near-immunity to primary cancer through the Morphogenic Tension Principle.
Primary cardiac tumors represent one of the most striking anomalies in clinical oncology, with a malignant incidence several orders of magnitude below that of all other major organ systems. While the prevailing mechanistic account attributes this near-immunity to the terminal post-mitotic state of adult cardiomyocytes, the present paper argues that this explanation, though accurate, lacks a unifying theoretical framework. Within the formal structure of the Morphogenic Tension Principle (MTP), the cardiac myocyte population is identified as the biological system in which the Morphogenic Dominance Index attains its maximum value across all human tissues a structural consequence of simultaneous maximal terminal differentiation, near-zero proliferative activity, constitutive Hippo pathway activation, and the effective absence of undifferentiated cellular reservoirs. This convergence is formalized as the Cardiac Morphogenic Supremacy Theorem, which establishes that the heart's resistance to primary cancer is not incidental but theoretically necessary and quantitatively derivable. The paper further derives four falsifiable predictions two computational, one experimental, and one clinico-genomic proposing the heart as a natural biological laboratory for the definitive empirical validation of MTP.
Momen Ghazouani (2026) studied Primary cardiac tumors. The Cardiac Morphogenic Supremacy Theorem is proposed to theoretically explain the heart's near-immunity to primary cancer through the Morphogenic Tension Principle.