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May 26, 2026Brain Research Bulletin0 citationsOpen Access

Brain Tau Network Derived Biomarker Improves the Diagnostic Accuracy of Alzheimer’s Disease

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TPTingting PanQZQi ZhouPLPanlong Li

Key Points

  • The study aims to assess the diagnostic accuracy of tau network characteristics for Alzheimer’s disease progression.
  • Evaluated tau-PET network characteristics in individuals across different stages: Healthy Control (HC), Mild Cognitive Impairment (MCI), and Alzheimer’s Disease (AD).
  • Assessed the relationship between tau network efficiency and ApoE4 positivity in MCI and AD.
  • Tracked longitudinal changes in tau network metrics to monitor disease progression at the individual level.
  • Tau network metrics significantly improved diagnostic accuracy over regional SUVR alone.
  • Global efficiency of the brain tau network correlated with Alzheimer’s disease progression, indicating its sensitivity as a biomarker.
  • ApoE4 positivity was linked to decreased tau network efficiency in MCI and AD patients.

Abstract

• Individual-level tau-PET network characteristics decline progressively from HC to MCI to AD. • Tau network metrics improve diagnostic accuracy over regional SUVR alone. • Global efficiency of the brain tau network is a sensitive biomarker for AD progression. • ApoE4 positivity is associated with reduced tau network efficiency in MCI and AD. • Longitudinal tau network changes track disease progression at the individual level.

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Cite This Study

Pan et al. (2026) studied this question.

synapsesocial.com/papers/6a153a2eb5d9c58d83e8cf5chttps://doi.org/10.1016/j.brainresbull.2026.111962
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