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May 26, 2026Journal of Biological ChemistryOpen Access

Cytosolic Heat Shock Protein 90 is Required for Photoreceptor Outer Segment Development and Vision.

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Authors

HAHunter AliffACAlexis B. CrockettDMDaniella Munezero

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Overview

Randomized trial reveals that cytosolic HSP90 is crucial for appropriate photoreceptor function and development, indicating its importance in vision.

Key Points

  • This research investigates the role of cytosolic heat shock protein 90 (HSP90) in photoreceptor outer segment development and visual function.
  • Generated conditional knockout of HSP90β in mice for analysis.
  • Conducted cone-specific ablation of both cytosolic HSP90 paralogs.
  • Examined retinal morphology and visual responses to assess functional outcomes.
  • Cone-specific loss of HSP90 activity led to rapid loss of cone function.
  • Targeted deletion of both HSP90 paralogs resulted in abolished visual responses and outer segment elaboration.
  • Reduced levels of peripherin were correlated with severe visual phenotype.

Cite This Study

Aliff et al. (2026) studied this question.

synapsesocial.com/papers/6a153bdfb5d9c58d83e8d4b8https://doi.org/10.1016/j.jbc.2026.113192
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