3D quantitative regional thickening and wall motion measures obtained from cardiac MRI correlated strongly with expert clinical visual scoring (r=-0.79 for global wall thickening).
Observational (n=53)
3D quantitative regional thickening and wall motion measures obtained from MRI correlate strongly with expert clinical scoring, offering a reliable quantitative alternative to visual assessment.
Effect estimate: r = -0.79
p-value: p=<0.0001
PURPOSE: To develop 3D quantitative measures of regional myocardial wall motion and thickening using cardiac magnetic resonance imaging (MRI) and to validate them by comparison to standard visual scoring assessment. MATERIALS AND METHODS: In all, 53 consecutive subjects with short-axis slices and mid-ventricular 2-chamber/4-chamber views were analyzed. After correction for breath-hold-related misregistration, 3D myocardial boundaries were fitted to images and edited by an imaging cardiologist. Myocardial thickness was quantified at end-diastole and end-systole by computing the 3D distances using Laplace's equation. 3D thickening was represented using the standard 17-segment polar coordinates. 3D thickening was compared with 3D wall motion and with expert visual scores (6-point visual scoring of wall motion and wall thickening; 0 = normal; 5 = greatest abnormality) assigned by imaging cardiologists. RESULTS: Correlation between ejection fraction and thickening measurements was (r = 0.84; P < 0.001) compared to correlation between ejection fraction and motion measurements (r = 0.86; P < 0.001). Good negative correlation between summed visual scores and global wall thickening and motion measurements were also obtained (r(thick) = -0.79; r(motion) = -0.74). Additionally, overall good correlation between individual segmental visual scores with thickening/wall motion (r(thick) = -0.69; r(motion) = -0.65) was observed (P < 0.0001). CONCLUSION: 3D quantitative regional thickening and wall motion measures obtained from MRI correlate strongly with expert clinical scoring.
Prasad et al. (2010) reported an observational. 3D quantitative measures of regional myocardial wall motion and thickening using cardiac MRI vs. Standard visual scoring assessment was evaluated on Correlation between 3D thickening/wall motion and expert visual scores (r = -0.79, p=<0.0001). 3D quantitative regional thickening and wall motion measures obtained from cardiac MRI correlated strongly with expert clinical visual scoring (r=-0.79 for global wall thickening).