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January 1, 1984Endocrinology

Rapid Effects of Angiotensin-I I on Polyphosphoinositide Metabolism in the Rat Adrenal Glomerulosa

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Why the study?

Does Angiotensin-II affect polyphosphoinositide metabolism in rat adrenal glomerulosa cells?

Population

32P-prelabeled rat adrenal glomerulosa cells

Comparison

Angiotensin-II (A-II) vs Other aldosterone-stimulating agents

Design

Preclinical

Follow-up

5 seconds

Authors

RFRobert V. FareseRLRonald E. LarsonJDJohn S. Davis

Discussion

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Overview

Hypothesis-generating for Ang-II calcium signaling via TPI in glomerulosa cells; leaves open human relevance.

Structured PICO

Does Angiotensin-II affect polyphosphoinositide metabolism in rat adrenal glomerulosa cells?

P
Population
32P-prelabeled rat adrenal glomerulosa cells
I
Intervention
Angiotensin-II (A-II)
C
Comparator
Other aldosterone-stimulating agents (ACTH, K+ and serotonin)
O
Outcome
Decrease in 32P in triphosphoinositide (TPI)surrogate

Angiotensin-II induces rapid triphosphoinositide hydrolysis in rat adrenal glomerulosa cells, suggesting a potential mechanism for calcium mobilization during its action.

Cite This Study

Farese et al. (1984) studied this question.

synapsesocial.com/papers/6a156b42814bf8ec9a4e907chttps://doi.org/10.1210/endo-114-1-302
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