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October 28, 2020Blood Advances57 citationsOpen Access

Outcome of patients with IDH1/2-mutated post–myeloproliferative neoplasm AML in the era of IDH inhibitors

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HCHelen T. ChifotidesLMLucia MasárováMAMansour Alfayez

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Abstract

Key Points IDH1/2-inhibitor–based combinations conferred significant clinical responses in patients with IDH1/2-mutated post–MPN AML. Complete remission was achieved in 3/7 patients (1 attaining MRD–) with new IDH1/2-mutated post–MPN AML treated with IDH1/2-i combinations.

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Chifotides et al. (2020) studied this question.

synapsesocial.com/papers/6a1618567fedbd43eb949ae0https://doi.org/10.1182/bloodadvances.2020001528
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