Background: Extracorporeal cardiopulmonary resuscitation (ECPR) has emerged as a promising strategy for refractory cardiac arrest, enabling the restoration of systemic perfusion when conventional resuscitation fails. However, uncertainties remain regarding patient selection, timing and implementation. Methods: A narrative review of experimental data, clinical studies, randomized trials and international recommendations was performed. Particular emphasis was placed on the interplay between physiological mechanisms, real-world organizational models and decision-making processes. Results: ECPR can restore effective circulation, preserve end organ perfusion and serve as a bridge to definitive etiologic treatment, with the potential to improve survival and neurological outcomes in highly selected patients. However, its effectiveness is strongly dependent on rapid deployment, structured systems of care and multidisciplinary coordination. Significant challenges remain, including in relation to the heterogeneity of protocols, high resource utilization, complications with extracorporeal support and the complexity of post-resuscitation management. Furthermore, ECPR fundamentally alters traditional resuscitation paradigms, introducing ethical dilemmas related to patient selection, prognostication and the allocation of limited resources. Conclusions: ECPR represents a transition from procedure-based resuscitation to system-based extracorporeal support. Its clinical benefit is contingent upon timely implementation within optimized organizational frameworks and integration with definitive treatment pathways. Future research should focus on refining selection criteria, standardizing care pathways and addressing ethical sustainability challenges to ensure appropriate and effective use of this evolving technology.
Torre et al. (2026) studied this question.