A porcine model of heart failure with preserved ejection fraction (HFpEF)

Key Points

• To develop a porcine model of heart failure with preserved ejection fraction (HFpEF) to better understand its pathophysiology.
• Developed a porcine model to study HFpEF characteristics and related interventions.
• Performed echocardiographic assessments to evaluate cardiac function and ventricular stiffness.
• Analyzed myocardial tissue samples for fibrosis and other biomarkers of heart failure.
• The porcine model exhibited significant myocardial fibrosis compared to healthy controls (p<0.05).
• Ejection fraction remained preserved in HFpEF model despite increased ventricular stiffness (p<0.01).
• Elevated biomarkers associated with heart failure were identified, suggesting potential therapeutic targets.