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Article AbstractBackground: This pilot study compared the efficacy of lithium plus divalproex sodium with the efficacy of lithium alone for the continuation and maintenance treatment of patients with bipolar I disorder. Method: Twelve patients with bipolar I disorder as defined by the DSMIIIR were recruited and followed prospectively for up to 1 year. Each subject received lithium at serum levels of 0.8 to 1.0 mmol/L and a management/education session weekly or every 2 weeks. By random assignment, subjects received either divalproex sodium or placebo in conjunction with lithium. Divalproex sodium was adjusted to achieve a serum concentration of 50 to 125 mg/mL. Adjunctive medications were used on an as needed basis to treat psychosis, depression, and anxiety. The course of illness was monitored through use of the Longitudinal Interval Followup Examination. Results: Subjects treated with the combination of lithium and divalproex were significantly less likely to suffer a relapse or recurrence (p=.014), but were significantly more likely to suffer at least one moderate or severe adverse side effect (p=.041). There was no significant difference between groups in the use of adjunctive medication. Conclusion: These results provide preliminary evidence of the risks and benefits of combining lithium with divalproex sodium for the continuation and maintenance treatment of bipolar I disorder.
Solomon et al. (1997) studied this question.