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September 20, 2018Haematologica210 citationsOpen Access

Daratumumab plus lenalidomide and dexamethasone versus lenalidomide and dexamethasone in relapsed or refractory multiple myeloma: updated analysis of POLLUX

MDMeletios Α. DimopoulosJMJesús F. San MiguelABAndrew R. Belch

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Abstract

In the POLLUX study, daratumumab plus lenalidomide/dexamethasone significantly reduced risk of progression/death versus lenalidomide/dexamethasone alone in relapsed/refractory multiple myeloma. We provide one additional year of follow up and include the effect on minimal residual disease and in clinically relevant subgroups. After 25.4 months of follow up, daratumumab plus lenalidomide/dexamethasone prolonged progression-free survival versus lenalidomide/dexamethasone alone (median not reached vs. 17.5 months; hazard ratio, 0.41; 95% confidence interval, 0.31-0.53; P

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Dimopoulos et al. (2018) studied this question.

synapsesocial.com/papers/6a16e85287c007abbc053636https://doi.org/10.3324/haematol.2018.194282
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