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May 26, 2010European Heart Journal174 citationsOpen Access

Pulmonary arterial hypertension: from the kingdom of the near-dead to multiple clinical trial meta-analyses

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NGNazzareno GalièMPMassimiliano PalazziniAMAlessandra Manes

Key Points

  • This research aims to examine the progression and clinical implications of pulmonary arterial hypertension (PAH) and its management through meta-analyses.
  • Conducted meta-analyses of multiple clinical trials focusing on pulmonary arterial hypertension treatments.
  • Analyzed data from diverse patient subgroups with varying pathologic changes in PAH.
  • Meta-analyses indicate a significant increase in survival rates for patients treated for PAH compared to controls.
  • Highlighted improvements in right ventricular function associated with specific therapeutic interventions.

Abstract

Pulmonary arterial hypertension (PAH) is a rare and severe clinical condition characterized by a progressive increase of pulmonary vascular resistance leading to right ventricular failure and premature death (Figure PAH in adults includes at least nine clinical subgroups with virtually identical obstructive pathologic changes (Figures

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Cite This Study

Galiè et al. (2010) studied this question.

synapsesocial.com/papers/6a177ceb8008e5848e6eb4bchttps://doi.org/10.1093/eurheartj/ehq152
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